In Vitro Susceptibility Testing Methods for Caspofungin against Aspergillus and Fusarium Isolates-Reference-Cited by-同舟云学术

In Vitro Susceptibility Testing Methods for Caspofungin against Aspergillus and Fusarium Isolates

Published:2001-01 Issue:1 Volume:45 Page:327-330
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Arikan Sevtap¹,Lozano-Chiu Mario¹,Paetznick Victor¹,Rex John H.¹

Affiliation:

1. Division of Infectious Diseases, Department of Internal Medicine, Center for the Study of Emerging and Reemerging Pathogens, University of Texas Medical School, Houston, Texas 77030

Abstract

ABSTRACT We investigated the relevance of prominent reduction in turbidity macroscopically (MIC) and formation of aberrant hyphal tips microscopically (minimum effective concentration; MEC) in measuring the in vitro activity of caspofungin against Aspergillus and Fusarium . Caspofungin generated low MICs and MECs against Aspergillus , but not for Fusarium . While MICs increased inconsistently when the incubation time was prolonged, MEC appeared as a stable and potentially relevant endpoint in testing in vitro caspofungin activity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.1.327-330.2001

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