Rapid Emergence of High-Level Resistance to Quinolones in Campylobacter jejuni Associated with Mutational Changes in gyrA and parC-Reference-Cited by-同舟云学术

Rapid Emergence of High-Level Resistance to Quinolones in Campylobacter jejuni Associated with Mutational Changes in gyrA and parC

Published:1998-12 Issue:12 Volume:42 Page:3276-3278
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Gibreel Amera¹,Sjögren Eva²,Kaijser Bertil²,Wretlind Bengt³,Sköld Ola¹

Affiliation:

1. Division of Microbiology, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Uppsala,1

2. Department of Clinical Bacteriology, Göteborg University, Göteborg,2 and

3. Bacteriological Laboratory, Karolinska Hospital, Stockholm,3Sweden

Abstract

ABSTRACT Quinolone resistance in clinical isolates of Campylobacter jejuni in Sweden increased more than 20-fold at the beginning of the 1990s. Resistance to 125 μg of ciprofloxacin per ml in clinical isolates was associated with chromosomal mutations in C. jejuni leading to a Thr-86-Ile substitution in the gyrA product and a Arg-139-Gln substitution in the parC product.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.42.12.3276

Reference24 articles.

1. Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV

2. Evidence for an efflux pump in multidrug-resistant Campylobacter jejuni

3. Endogenous active efflux of norfloxacin in susceptible Escherichia coli

4. Adaptation to sulfonamide resistance in Neisseria meningitidis may have required compensatory changes to retain enzyme function: kinetic analysis of dihydropteroate synthases from N. meningitidis expressed in a knockout mutant of Escherichia coli

5. Genetic and biochemical characterization of norfloxacin resistance in Escherichia coli

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