Immune Screening Identifies Novel T Cell Targets Encoded by Antisense Reading Frames of HIV-1-Reference-Cited by-同舟云学术

Immune Screening Identifies Novel T Cell Targets Encoded by Antisense Reading Frames of HIV-1

Published:2015-04 Issue:7 Volume:89 Page:4015-4019
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Berger Christoph T.¹²^ORCID,Llano Anuska³,Carlson Jonathan M.⁴,Brumme Zabrina L.⁵⁶,Brockman Mark A.⁵⁶,Cedeño Samandhy³,Harrigan P. Richard⁶,Kaufmann Daniel E.¹⁷,Heckerman David⁴,Meyerhans Andreas⁸⁹,Brander Christian³⁹¹⁰¹¹

Affiliation:

1. Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA

2. Translational Immunology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland

3. IrsiCaixa AIDS Research Institute-HIVACAT, Hospital Germans Trias I Pujol, Badalona, Spain

4. Microsoft Research, Seattle, Washington, USA

5. Simon Fraser University, Burnaby, BC, Canada

6. British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada

7. University of Montreal Hospital Research Center (CRCHUM), Montreal, QC, Canada

8. Infection Biology Group, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain

9. Institucio Catalana de Recerca i Estudis Avancats (ICREA), Barcelona, Spain

10. University of Vic and Central University of Catalonia, Vic, Catalonia, Spain

11. Autonomous University of Barcelona, Barcelona, Catalonia, Spain

Abstract

ABSTRACT Cytotoxic-T lymphocyte (CTL) responses to epitopes in alternative HIV reading frames have been reported. However, the extent of CTL responses to putative proteins encoded in antisense reading frames is unknown. Using sequence alignments and computational approaches, we here predict five potential antisense HIV proteins and characterize common CTL responses against them. Results suggest that antisense-derived sequences are commonly transcribed and translated and could encode functional proteins that contain important targets of anti-HIV cellular immunity.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.03435-14

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