Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 + Lymphocytes-Reference-Cited by-同舟云学术

Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 + Lymphocytes

Published:1999-02-05 Issue:5403 Volume:283 Page:857-860
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Schmitz Jörn E.¹,Kuroda Marcelo J.¹,Santra Sampa¹,Sasseville Vito G.²,Simon Meredith A.²,Lifton Michelle A.¹,Racz Paul³,Tenner-Racz Klara³,Dalesandro Margaret⁴,Scallon Bernhard J.⁴,Ghrayeb John⁴,Forman Meryl A.⁵,Montefiori David C.⁶,Rieber E. Peter⁷,Letvin Norman L.¹,Reimann Keith A.¹

Affiliation:

1. Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

2. New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA.

3. Bernhard-Nocht-Institute for Tropical Medicine, 20359 Hamburg, Germany.

4. Centocor, Malvern, PA 19355, USA.

5. Beckman Coulter, Miami, FL 33196, USA.

6. Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.

7. Institute of Immunology, Technical University of Dresden, 01101 Dresden, Germany.

Abstract

Clinical evidence suggests that cellular immunity is involved in controlling human immunodeficiency virus–1 (HIV-1) replication. An animal model of acquired immune deficiency syndrome (AIDS), the simian immunodeficiency virus (SIV)–infected rhesus monkey, was used to show that virus replication is not controlled in monkeys depleted of CD8 + lymphocytes during primary SIV infection. Eliminating CD8 + lymphocytes from monkeys during chronic SIV infection resulted in a rapid and marked increase in viremia that was again suppressed coincident with the reappearance of SIV-specific CD8 + T cells. These results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference25 articles.

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5. Cytotoxic-T-Cell Responses, Viral Load, and Disease Progression in Early Human Immunodeficiency Virus Type 1 Infection

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