Biological Trojan Horse: Antigen 43 Provides Specific Bacterial Uptake and Survival in Human Neutrophils-Reference-Cited by-同舟云学术

Biological Trojan Horse: Antigen 43 Provides Specific Bacterial Uptake and Survival in Human Neutrophils

Published:2007-01 Issue:1 Volume:75 Page:30-34
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Fexby Sara¹,Bjarnsholt Thomas¹,Jensen Peter Østrup²,Roos Viktoria¹,Høiby Niels²,Givskov Michael¹,Klemm Per¹

Affiliation:

1. Center for Biomedical Microbiology, BioCentrum-DTU, Technical University of Denmark, Lyngby, Denmark

2. Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark

Abstract

ABSTRACT Escherichia coli is a versatile pathogen causing millions of infections in humans every year. This bacterium can form multicellular aggregates when it expresses a self-associating protein, antigen 43 (Ag43), on its surface. We have discovered that Ag43-expressing E. coli cells are efficiently taken up by human defense cells, polymorphonuclear neutrophils (PMNs), in an opsonin-independent manner. Surprisingly, the phagocytosed bacteria were not immediately killed but resided as tight aggregates within the PMNs. Our observations indicate that Ag43-mediated uptake and survival in PMNs constitute a mechanism to subvert one of the primary defense mechanisms of the human body.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.01117-06

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