Bacterial Biofilms: A Common Cause of Persistent Infections-Reference-Cited by-同舟云学术

Bacterial Biofilms: A Common Cause of Persistent Infections

Published:1999-05-21 Issue:5418 Volume:284 Page:1318-1322
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Costerton J. W.¹,Stewart Philip S.¹,Greenberg E. P.²

Affiliation:

1. Center for Biofilm Engineering, Montana State University, Bozeman, MT 59717, USA.

2. Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.

Abstract

Bacteria that attach to surfaces aggregate in a hydrated polymeric matrix of their own synthesis to form biofilms. Formation of these sessile communities and their inherent resistance to antimicrobial agents are at the root of many persistent and chronic bacterial infections. Studies of biofilms have revealed differentiated, structured groups of cells with community properties. Recent advances in our understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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