Pharmacokinetics and Ex Vivo Antimalarial Activity of Artesunate-Amodiaquine plus Methylene Blue in Healthy Volunteers-Reference-Cited by-同舟云学术

Pharmacokinetics and Ex Vivo Antimalarial Activity of Artesunate-Amodiaquine plus Methylene Blue in Healthy Volunteers

Published:2020-02-21 Issue:3 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Anh Chu Xuan¹,Chavchich Marina²,Birrell Geoffrey W.²,Van Breda Karin²,Travers Thomas²,Rowcliffe Kerryn²,Lord Anton R.³,Shanks G. Dennis²,Edstein Michael D.²

Affiliation:

1. Institute for Clinical Infectious Diseases, Central Military Hospital 108, Hanoi, Vietnam

2. Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, Australia

3. Queensland Institute of Medical Research Berghofer, Brisbane, Australia

Abstract

High rates of artemisinin-based combination therapy (ACT) failures in the treatment of Plasmodium falciparum malaria in Southeast Asia have led to triple-drug strategies to extend the useful life of ACTs. In this study, we determined whether methylene blue [MB; 3,7-bis(dimethylamino)phenothiazin-5-ium chloride hydrate] alters the pharmacokinetics of artesunate-amodiaquine (ASAQ) and enhances the ex vivo antimalarial activity of ASAQ.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01441-19

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