Investigating the Efficacy of Triple Artemisinin-Based Combination Therapies for Treating Plasmodium falciparum Malaria Patients Using Mathematical Modeling

Author:

Dini Saber1,Zaloumis Sophie1ORCID,Cao Pengxing2,Price Ric N.34,Fowkes Freya J. I.156,van der Pluijm Rob W.47,McCaw James M.1289,Simpson Julie A.1

Affiliation:

1. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia

2. School of Mathematics and Statistics, University of Melbourne, Melbourne, Australia

3. Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Casuarina, Australia

4. Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

5. Burnet Institute, Disease Elimination Program, Public Health, Melbourne, Australia

6. Department of Epidemiology and Preventative Medicine and Department of Infectious Diseases, Monash University, Melbourne, Australia

7. Mahidol Oxford Tropical Medicine Research Unit, Bangkok, Thailand

8. Peter Doherty Institute for Infection and Immunity, The Royal Melbourne Hospital and University of Melbourne, Melbourne, Australia

9. Murdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, Australia

Abstract

The first line treatment for uncomplicated falciparum malaria is artemisinin-based combination therapy (ACT), which consists of an artemisinin derivative coadministered with a longer-acting partner drug. However, the spread of Plasmodium falciparum resistant to both artemisinin and its partner drugs poses a major global threat to malaria control activities.

Funder

NHMRC Project

ARC Discovery Project

Wellcome Trust Senior Fellow in Clinical Sciences

NHMRC Centre for Research Excellence in Malaria Elimination

Victorian Center for Biostatistics

NHMRC Senior Research Fellow

NHMRC Centre for Research Excellence in Infectious Disease Modelling to Inform Public Health Policy

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference53 articles.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3