Efficient Nef-Mediated Downmodulation of TCR-CD3 and CD28 Is Associated with High CD4+ T Cell Counts in Viremic HIV-2 Infection

Author:

Khalid M.,Yu H.,Sauter D.,Usmani S. M.,Schmokel J.,Feldman J.,Gruters R. A.,van der Ende M. E.,Geyer M.,Rowland-Jones S.,Osterhaus A. D.,Kirchhoff F.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference60 articles.

1. Nef-induced major histocompatibility complex class I downregulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 downregulation;Akari;J. Virol.,2000

2. The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses;Arhel;J. Clin. Investig.,2009

3. Low peripheral blood viral HIV-2 RNA in individuals with high CD4 percentage differentiates HIV-2 from HIV-1 infection;Berry;J. Hum. Virol.,1998

4. CCR5, GPR15, and CXCR6 are major coreceptors of human immunodeficiency virus type 2 variants isolated from individuals with and without plasma viremia;Blaak;J. Virol.,2005

5. HIV-2-infected individuals with undetectable plasma viremia carry replication-competent virus in peripheral blood lymphocytes;Blaak;J. Acquir. Immune Defic. Syndr.,2004

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