Substitutions in Nef That Uncouple Tetherin and SERINC5 Antagonism Impair Simian Immunodeficiency Virus Replication in Primary Rhesus Macaque Lymphocytes-Reference-Cited by-同舟云学术

Substitutions in Nef That Uncouple Tetherin and SERINC5 Antagonism Impair Simian Immunodeficiency Virus Replication in Primary Rhesus Macaque Lymphocytes

Published:2022-06-08 Issue:11 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Janaka Sanath Kumar¹,Snow Brian J.¹^ORCID,Behrens Ryan T.¹^ORCID,Evans David T.¹²^ORCID

Affiliation:

1. Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA

2. Wisconsin National Primate Research Center, Madison, Wisconsin, USA

Abstract

Tetherin is an interferon-inducible transmembrane protein that prevents the detachment of enveloped viruses from infected cells by physically tethering nascent virions to cellular membranes. SIV Nef downmodulates simian tetherin to overcome this restriction in nonhuman primate hosts.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00176-22

Reference57 articles.

1. Direct Restriction of Virus Release and Incorporation of the Interferon-Induced Protein BST-2 into HIV-1 Particles

2. Immunoelectron Microscopic Evidence for Tetherin/BST2 as the Physical Bridge between HIV-1 Virions and the Plasma Membrane

3. Bst-2/HM1.24 Is a Raft-Associated Apical Membrane Protein with an Unusual Topology

4. Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

5. Tetherin Inhibits HIV-1 Release by Directly Tethering Virions to Cells

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