Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs-Reference-Cited by-同舟云学术

Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Gobeil Sophie M.-C.¹²,Bobay Benjamin G.³,Juvvadi Praveen R.⁴,Cole D. Christopher⁴,Heitman Joseph⁵,Steinbach William J.⁴⁵,Venters Ronald A.³,Spicer Leonard D.¹²³

Affiliation:

1. Department of Biochemistry, Duke University, Durham, North Carolina, USA

2. Department of Radiology, Duke University, Durham, North Carolina, USA

3. Duke University NMR Center, Duke University Medical Center, Durham, North Carolina, USA

4. Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA

5. Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA

Abstract

Invasive fungal infections are a leading cause of death in the immunocompromised patient population. The rise in drug resistance to current antifungals highlights the urgent need to develop more efficacious and highly selective agents.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03000-21

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