Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity-Reference-Cited by-同舟云学术

Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity

Published:2021-01-14 Issue:2 Volume:64 Page:1139-1169
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Marcyk Paul T.¹^ORCID,LeBlanc Emmanuelle V.²^ORCID,Kuntz Douglas A.³,Xue Alice²,Ortiz Francisco⁴,Trilles Richard¹,Bengtson Stephen¹^ORCID,Kenney Tristan M. G.⁵^ORCID,Huang David S.¹^ORCID,Robbins Nicole²,Williams Noelle S.⁴,Krysan Damian J.⁶,Privé Gilbert G.³⁵⁷,Whitesell Luke²,Cowen Leah E.²^ORCID,Brown Lauren E.¹^ORCID

Affiliation:

1. Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University, Boston, Massachusetts 02215, United States

2. Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1M1, Canada

3. Princess Margaret Cancer Centre, Toronto, Ontario M5G 1L7, Canada

4. Department of Biochemistry, UT Southwestern Medical Center, Dallas, Texas 75390-9038, United States

5. Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada

6. Departments of Pediatrics and Microbiology/Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States

7. Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada

Funder

Samuel Waxman Cancer Research Foundation

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Natural Sciences and Engineering Research Council of Canada

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01777

Reference90 articles.

1. Hidden Killers: Human Fungal Infections

2. Worldwide emergence of resistance to antifungal drugs challenges human health and food security

3. Tackling Human Fungal Infections

4. Epidemiology of Invasive Mycoses in North America

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