Affiliation:
1. Department of Biochemistry and Molecular Biology, Albany Medical College, Albany, New York 122081
2. Department of Microbiology, The Ohio State University, Columbus, Ohio 43210,2 and
Abstract
ABSTRACT
A large number of carbon source utilization pathways are repressed in
Bacillus subtilis
by the global regulator CcpA, which also acts as an activator of carbon excretion pathways during growth in media containing glucose. In this study, CcpA mutants defective in transcriptional activation of the
alsSD
operon, which is involved in acetoin biosynthesis, were identified. These mutants retained normal glucose repression of
amyE
, encoding α-amylase, and
acsA
, encoding acetyl-coenzyme A synthetase, and normal activation of
ackA
, which is involved in acetate excretion; in these
ccpA
mutants the CcpA functions of activation of the acetate and acetoin excretion pathways appear to be separated.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
40 articles.
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