PMRT1, a <i>Plasmodium</i> -Specific Parasite Plasma Membrane Transporter, Is Essential for Asexual and Sexual Blood Stage Development-Reference-Cited by-同舟云学术

PMRT1, a Plasmodium -Specific Parasite Plasma Membrane Transporter, Is Essential for Asexual and Sexual Blood Stage Development

Published:2022-04-26 Issue:2 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Wichers Jan Stephan¹²³^ORCID,Mesén-Ramírez Paolo²^ORCID,Fuchs Gwendolin¹²³^ORCID,Yu-Strzelczyk Jing⁴^ORCID,Stäcker Jan²^ORCID,von Thien Heidrun¹²,Alder Arne¹²³^ORCID,Henshall Isabelle⁵^ORCID,Liffner Benjamin⁵^ORCID,Nagel Georg⁴^ORCID,Löw Christian¹⁶^ORCID,Wilson Danny⁵⁷,Spielmann Tobias²^ORCID,Gao Shiqiang⁴^ORCID,Gilberger Tim-Wolf¹²³,Bachmann Anna¹²³^ORCID,Strauss Jan¹²³⁶^ORCID

Affiliation:

1. Centre for Structural Systems Biology, Hamburg, Germany

2. Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

3. Biology Department, University of Hamburg, Hamburg, Germany

4. Institute of Physiology, Department of Neurophysiology, Biocenter, University of Würzburg, Würzburg, Germany

5. Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, Australia

6. European Molecular Biology Laboratory, Hamburg Unit, Hamburg, Germany

7. Burnet Institute, Melbourne, Victoria, Australia

Abstract

Plasmodium falciparum -infected erythrocytes possess multiple compartments with designated membranes. Transporter proteins embedded in these membranes not only facilitate movement of nutrients, metabolites, and other molecules between these compartments, but also are common therapeutic targets and can confer antimalarial drug resistance.

Funder

Deutsche Forschungsgemeinschaft

Partnership of University of Hamburg and DESY

Centre for Structural Systems Biology

Hospital Research Foundation

Deutscher Akademischer Austauschdienst

Australian Government

Jürgen Manchot Stiftung

Publisher

American Society for Microbiology

Subject

Virology,Microbiology