A Microtubule-Associated Protein Is Essential for Malaria Parasite Transmission

Author:

Wichers-Misterek Jan Stephan123ORCID,Binder Annika M.4ORCID,Mesén-Ramírez Paolo123ORCID,Dorner Lilian Patrick4,Safavi Soraya123ORCID,Fuchs Gwendolin123ORCID,Lenz Tobias L.35ORCID,Bachmann Anna1236ORCID,Wilson Danny789ORCID,Frischknecht Friedrich410ORCID,Gilberger Tim-Wolf123ORCID

Affiliation:

1. Centre for Structural Systems Biology, Hamburg, Germany

2. Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

3. Biology Department, University of Hamburg, Hamburg, Germany

4. Integrative Parasitology, Department of Infectious Diseases, Heidelberg University Medical School, Heidelberg, Germany

5. Research Unit for Evolutionary Immunogenomics, Department of Biology, University of Hamburg, Hamburg, Germany

6. German Center for Infection Research, Partner Site Hamburg-Borstel-Lübeck-Riems, Hamburg, Germany

7. Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia

8. Burnet Institute, Melbourne, Victoria, Australia

9. Institute for Photonics and Advanced Sensing, University of Adelaide, Adelaide, South Australia, Australia

10. German Center for Infection Research, Partner Site Heidelberg, Heidelberg, Germany

Abstract

A key structural feature driving the transition between different life cycle stages of the malaria parasite is the unique three-membrane pellicle, consisting of the parasite plasma membrane (PPM) and a double membrane structure underlying the PPM termed the inner membrane complex (IMC). Additionally, there are numerous linearly arranged intramembranous particles (IMPs) linked to the IMC, which likely link the IMC to the subpellicular microtubule cytoskeleton.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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