Dihydroartemisinin Disrupts Zinc Homeostasis in Plasmodium falciparum To Potentiate Its Antimalarial Action via Pyknosis

Author:

Asahi Hiroko1,Niikura Mamoru2,Inoue Shin-Ichi3,Sendo Fujiro4,Kobayashi Fumie5,Wada Akira1ORCID

Affiliation:

1. Laboratory for Nonnatural Amino Acid Technology, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan

2. Division of Tropical Diseases and Parasitology, Department of Infectious Diseases, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan

3. Division of Immunology, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Nagasaki 852-8523, Japan

4. Kojunosato, Geriatric Health Service Facilities, 8-1 Azahonmaru, Oazamizonobe, Kahoku-cho, Yamagata 999-3522, Japan

5. Department of Environmental Science, School of Life and Environmental Science, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan

Funder

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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