Amoeba Predation of Cryptococcus neoformans Results in Pleiotropic Changes to Traits Associated with Virulence-Reference-Cited by-同舟云学术

Amoeba Predation of Cryptococcus neoformans Results in Pleiotropic Changes to Traits Associated with Virulence

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Fu Man Shun¹,Liporagi-Lopes Livia C.¹²,dos Santos Samuel R.¹³,Tenor Jennifer L.⁴,Perfect John R.⁴,Cuomo Christina A.⁵^ORCID,Casadevall Arturo¹^ORCID

Affiliation:

1. Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

2. Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

3. Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil

4. Division of Infectious Diseases, Department of Medicine and Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA

5. Infectious Disease and Microbiome Program, Broad Institute, Cambridge, Massachusetts, USA

Abstract

Cryptococcus neoformans is a ubiquitous environmental fungus that is also a leading cause of fatal fungal infection in humans, especially among immunocompromised patients. A major question in the field is how an environmental yeast such as C. neoformans becomes a human pathogen when it has no need for an animal host in its life cycle.

Funder

HHS | National Institutes of Health

HHS | U.S. Public Health Service

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00567-21

Reference98 articles.

1. Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis

2. Ingestion of acapsular Cryptococcus neoformans occurs via mannose and beta-glucan receptors, resulting in cytokine production and increased phagocytosis of the encapsulated form