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Distinct pathways of adaptive evolution in Cryptococcus neoformans reveal a mutation in adenylyl cyclase with trade-offs for pathogenicity

  • Published:2023-10 Issue:19 Volume:33 Page:4136-4149.e9
  • ISSN:0960-9822
  • Container-title:Current Biology
  • language:en
  • Short-container-title:Current Biology

Author:

Hilbert Zoë A.,Bednarek Joseph M.,Schwiesow Mara J.W.,Chung Krystal Y.,Moreau Christian T.,Brown Jessica C.S.,Elde Nels C.ORCID

Funder

National Institutes of Health

Burroughs Wellcome Fund

Helen Hay Whitney Foundation

Publisher

Elsevier BV

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

Reference87 articles.

1. Deciphering the model pathogenic fungus Cryptococcus neoformans;Idnurm;Nat. Rev. Microbiol.,2005

2. Associations between Cryptococcus genotypes, phenotypes, and clinical parameters of human disease: a review;Montoya;J. Fungi (Basel),2021

3. The global burden of HIV-associated cryptococcal infection in adults in 2020: a modelling analysis;Rajasingham;Lancet Infect. Dis.,2022

4. Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans;Desjardins;Genome Res.,2017

5. Comparative analyses of clinical and environmental populations of Cryptococcus neoformans in Botswana;Chen;Mol. Ecol.,2015

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