Plasma Proteomic Analysis Distinguishes Severity Outcomes of Human Ebola Virus Disease-Reference-Cited by-同舟云学术

Plasma Proteomic Analysis Distinguishes Severity Outcomes of Human Ebola Virus Disease

Published:2022-06-28 Issue:3 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Viodé Arthur¹²,Smolen Kinga K.²³⁴,Fatou Benoit¹²³,Wurie Zainab¹,Van Zalm Patrick¹²,Konde Mandy Kader⁵⁶,Keita Balla Moussa⁵⁶,Ablam Richard Amento⁵,Fish Eleanor N.⁷⁸,Steen Hanno¹²³

Affiliation:

1. Department of Pathology, Boston Children’s Hospital, Boston, Massachusetts, USA

2. Harvard Medical School, Boston, Massachusetts, USA

3. Precision Vaccines Program, Boston Children’s Hospital, Boston, Massachusetts, USA

4. Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, USA

5. Sustainable Health Foundation (FOSAD), Conakry, Guinea

6. Center of Excellence for Training on Research and Priority Diseases (CEFORPAG), Conakry, Guinea

7. Toronto General Hospital Research Institute, University Health Network, Toronto, Canada

8. Department of Immunology, University of Toronto, Toronto, Canada

Abstract

As evidenced by the 2013–2016 outbreak in West Africa, Ebola virus (EBV) disease (EVD) poses a major global health threat. In this study, we characterized the plasma proteomes of 12 individuals infected with EBV, using two different LC-MS-based proteomics platforms and an antibody-based multiplexed cytokine/chemokine assay.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00567-22

Reference74 articles.

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2. Ebola virus disease

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5. The ebolavirus VP24 interferon antagonist

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