Mycobacterium tuberculosis Malate Synthase- and MPT51-Based Serodiagnostic Assay as an Adjunct to Rapid Identification of Pulmonary Tuberculosis-Reference-Cited by-同舟云学术

Mycobacterium tuberculosis Malate Synthase- and MPT51-Based Serodiagnostic Assay as an Adjunct to Rapid Identification of Pulmonary Tuberculosis

Published:2006-11 Issue:11 Volume:13 Page:1291-1293
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Achkar Jacqueline M.¹²³,Dong Yuxin¹²³,Holzman Robert S.¹²³,Belisle John¹²³,Kourbeti Irene S.¹²³,Sherpa Tsering¹²³,Condos Rany¹²³,Rom William N.¹²³,Laal Suman¹²³

Affiliation:

1. New York University School of Medicine, New York, New York 10016

2. Department of Veterans Affairs New York Harbor Health Care System, New York, New York 10010

3. Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523

Abstract

ABSTRACT The 81-kDa malate synthase (MS; Rv 1837c) and the 27-kDa MPT51 (Rv 3803c) of Mycobacterium tuberculosis are immunodominant antigens recognized by serum antibodies from ∼80% of human immunodeficiency virus-negative smear-positive tuberculosis patients from India. We now provide evidence that the use of the MS/MPT51-based serodiagnostic assay can serve as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00158-06

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