The modern characteristic of biology and diagnostics prospect M. tuberculosis

Abstract

Features of biology M. tuberculosis are considered the including modern data about features of morphology, the antigen structures of the various nature defining virulence of activators of tuberculosis. Based on the method data spoligothipirovanie genetic distinctions of families Mycobacteriaceae, and among them strains genotype Beijing, different by wide prevalence in the Russian Federation and high medicinal stability are especially characterised. Based on difficult antigens structure M. tuberculosis features of the development of the immune answer which allow predicting a current of the infectious process are reflected. The presented characteristics reflect considerable heterogeneity strains M. tuberculosis which is combined with a variety of an immune homeostasis of the carriers which were ill and by that essentially complicates laboratory diagnostics of tuberculosis. Among the considered modern methods of diagnostics of a tubercular infection, the most perspective can be immunologic. One of the ways of improvement serodiagnostic the tests promoting an increase of sensitivity serodiagnostic of tuberculosis is creation polyepitopes chimeric antigens by chemical synapsis fibres with carbohydrate molecules. Creation of a composition from several immunodominant antigens M. tuberculosis can become other direction of increase of sensitivity. that will allow lowering considerably number false-positive results. Creation of hybrid fibers will allow avoiding an inevitable decrease in affinity of antibodies of the way of the blood, arising at the use of several antigens simultaneously.