Recombinant Yellow Fever Vaccine Virus 17D Expressing Simian Immunodeficiency Virus SIVmac239 Gag Induces SIV-Specific CD8 + T-Cell Responses in Rhesus Macaques

Author:

Bonaldo Myrna C.1,Martins Mauricio A.2,Rudersdorf Richard2,Mudd Philip A.2,Sacha Jonah B.2,Piaskowski Shari M.2,Costa Neves Patrícia C.1,Veloso de Santana Marlon G.1,Vojnov Lara2,Capuano Saverio3,Rakasz Eva G.23,Wilson Nancy A.23,Fulkerson John4,Sadoff Jerald C.4,Watkins David I.23,Galler Ricardo5

Affiliation:

1. Laboratorio de Biologia Molecular de Flavivírus, Instituto Oswaldo Cruz—FIOCRUZ, Rio de Janeiro, Brazil

2. Department of Pathology and Laboratory Medicine, University of Wisconsin—Madison, Madison, Wisconsin

3. Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin

4. Aeras Global TB Vaccine Foundation, Rockville, Maryland

5. Instituto de Tecnologia em Imunobiologicos, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil

Abstract

ABSTRACT Here we describe a novel vaccine vector for expressing human immunodeficiency virus (HIV) antigens. We show that recombinant attenuated yellow fever vaccine virus 17D expressing simian immunodeficiency virus SIVmac239 Gag sequences can be used as a vector to generate SIV-specific CD8 + T-cell responses in the rhesus macaque. Priming with recombinant BCG expressing SIV antigens increased the frequency of these SIV-specific CD8 + T-cell responses after recombinant YF17D boosting. These recombinant YF17D-induced SIV-specific CD8 + T cells secreted several cytokines, were largely effector memory T cells, and suppressed viral replication in CD4 + T cells.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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