Effects of Cytotoxic T Lymphocytes (CTL) Directed against a Single Simian Immunodeficiency Virus (SIV) Gag CTL Epitope on the Course of SIVmac239 Infection-Reference-Cited by-同舟云学术

Effects of Cytotoxic T Lymphocytes (CTL) Directed against a Single Simian Immunodeficiency Virus (SIV) Gag CTL Epitope on the Course of SIVmac239 Infection

Published:2002-10-15 Issue:20 Volume:76 Page:10507-10511
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Allen Todd M.¹,Jing Peicheng¹,Calore Briana¹,Horton Helen¹,O'Connor David H.¹,Hanke Tomas²,Piekarczyk Marian¹,Ruddersdorf Richard¹,Mothé Bianca R.¹,Emerson Carol¹,Wilson Nancy¹,Lifson Jeffrey D.³,Belyakov Igor M.⁴,Berzofsky Jay A.⁴,Wang Chenxi⁵,Allison David B.⁵,Montefiori David C.⁶,Desrosiers Ronald C.⁷,Wolinsky Steven⁸,Kunstman Kevin J.⁸,Altman John D.⁹,Sette Alessandro¹⁰,McMichael Andrew J.²,Watkins David I.¹¹¹

Affiliation:

1. Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715

2. Institute of Molecular Medicine, John Radcliffe Hospital—Headington, Oxford OX3 9DS, United Kingdom

3. Retroviral Pathogenesis Laboratory, AIDS Vaccine Program, SAIC Frederick, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, Maryland 21702

4. National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892

5. Section on Statistical Genetics, Department of Biostatistics and Clinical Nutrition Research Center, University of Alabama—Birmingham, Birmingham, Alabama 35294

6. Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710

7. New England Regional Primate Research Center, Southborough, Massachusetts 01772

8. Northwestern University Medical School, Chicago, Illinois 60611-3010

9. Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322

10. Epimmune Inc., San Diego, California 92121

11. Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53706

Abstract

ABSTRACT Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques. Therefore, we wanted to test the impact that vaccine-induced CTL responses against an immunodominant Gag epitope might have in the absence of other immune responses. By themselves, these strong CTL responses failed to control SIVmac239 replication.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.76.20.10507-10511.2002

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