Tat-Vaccinated Macaques Do Not Control Simian Immunodeficiency Virus SIVmac239 Replication-Reference-Cited by-同舟云学术

Tat-Vaccinated Macaques Do Not Control Simian Immunodeficiency Virus SIVmac239 Replication

Published:2002-04-15 Issue:8 Volume:76 Page:4108-4112
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Allen Todd M.¹,Mortara Lorenzo¹,Mothé Bianca R.¹,Liebl Max¹,Jing Peicheng¹,Calore Briana¹,Piekarczyk Marian¹,Ruddersdorf Richard¹,O'Connor David H.¹,Wang X.²,Wang Chenxi³,Allison David B.³,Altman John D.²,Sette Alessandro⁴,Desrosiers Ronald C.⁵,Sutter Gerd⁶,Watkins David I.¹⁷

Affiliation:

1. Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715

2. Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322

3. Section on Statistical Genetics, Department of Biostatistics and Clinical Nutrition Research Center and Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294

4. Epimmune Inc., San Diego, California 92121

5. New England Regional Primate Research Center, Southborough, Massachusetts 01772

6. GSF-Institute for Molecular Virology, Munich, Germany 81675

7. Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53706

Abstract

ABSTRACT The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.76.8.4108-4112.2002

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