A Highly Unusual V1 Region of Env in an Elite Controller of HIV Infection-Reference-Cited by-同舟云学术

A Highly Unusual V1 Region of Env in an Elite Controller of HIV Infection

Published:2019-05-15 Issue:10 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Silver Zachary A.¹²,Dickinson Gordon M.³⁴,Seaman Michael S.⁵,Desrosiers Ronald C.²

Affiliation:

1. Medical Scientist Training Program, Miller School of Medicine, University of Miami, Miami, Florida, USA

2. Department of Pathology, Miller School of Medicine, University of Miami, Miami, Florida, USA

3. Infectious Diseases Section, Miami Veterans Affairs Health Care System, University of Miami, Miami, Florida, USA

4. Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida, USA

5. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

Abstract

Elite controllers have long provided an avenue for researchers to reveal mechanisms underlying control of HIV-1. While the role of host genetic factors in facilitating elite control is well known, the possibility of infection by attenuated strains of HIV-1 has been much less studied. Here we describe an unusual viral feature found in an elite controller of HIV-1 infection and demonstrate its role in conferring escape from monoclonal antibodies of the V3-glycan class. Our results suggest that extreme variation may be needed by HIV-1 to escape neutralization by some antibody specificities.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00094-19

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