Subtle Longitudinal Alterations in Env Sequence Potentiate Differences in Sensitivity to Broadly Neutralizing Antibodies following Acute HIV-1 Subtype C Infection-Reference-Cited by-同舟云学术

Subtle Longitudinal Alterations in Env Sequence Potentiate Differences in Sensitivity to Broadly Neutralizing Antibodies following Acute HIV-1 Subtype C Infection

Published:2022-12-21 Issue:24 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Mandizvo Tawanda¹²^ORCID,Gumede Nombali²,Ndlovu Bongiwe²,Ndlovu Siphiwe²^ORCID,Mann Jaclyn K.²,Chopera Denis R.¹²,Singh Lanish¹²,Dong Krista L.³,Walker Bruce D.²³,Ndhlovu Zaza M.¹²³,Lavine Christy L.⁴,Seaman Michael S.⁴,Gounder Kamini¹²^ORCID,Ndung’u Thumbi¹²³⁵^ORCID

Affiliation:

1. Africa Health Research Institute, Durban, South Africa

2. HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa

3. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts, USA

4. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

5. Division of Infection and Immunity, University College London, London, United Kingdom

Abstract

Broadly neutralizing antibodies (bNAbs) have potential clinical utility in HIV-1 prevention and cure strategies. However, bNAbs target diverse epitopes on the HIV-1 envelope and the virus may evolve to evade immune responses.

Funder

Bill and Melinda Gates Foundation

Gilead Sciences

International AIDS Vaccine Initiative

HHS | NIH | National Institute of Allergy and Infectious Diseases

Wellcome Trust

Global Challenges Research Fund

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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