Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection-Reference-Cited by-同舟云学术

Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection

Published:2016-09-28 Issue:358 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Muenchhoff Maximilian¹²³⁴,Adland Emily¹,Karimanzira Owen⁵,Crowther Carol⁵,Pace Matthew⁶⁷⁸,Csala Anna¹,Leitman Ellen¹,Moonsamy Angeline¹,McGregor Callum¹²,Hurst Jacob⁹,Groll Andreas¹⁰,Mori Masahiko¹,Sinmyee Smruti¹,Thobakgale Christina²,Tudor-Williams Gareth¹¹,Prendergast Andrew J.¹²,Kloverpris Henrik¹³¹⁴,Roider Julia¹²¹³,Leslie Alasdair¹³,Shingadia Delane¹⁵,Brits Thea¹⁶,Daniels Samantha¹⁶,Frater John⁶⁷⁸,Willberg Christian B.⁷⁸,Walker Bruce D.²¹⁷,Ndung’u Thumbi²¹³¹⁷¹⁸,Jooste Pieter¹⁶,Moore Penny L.⁵¹⁹²⁰,Morris Lynn⁵¹⁹²⁰,Goulder Philip¹²¹⁵

Affiliation:

1. Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, University of Oxford, Oxford OX1 3SY, U.K.

2. HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal (UKZN), Durban, South Africa.

3. Max von Pettenkofer-Institute, Department of Virology, Ludwig-Maximilians-University Munich, Munich, Germany.

4. German Center for Infection Research (DZIF), Partner Site Munich, Germany.

5. Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.

6. Institute for Emerging Infections, Oxford Martin School, University of Oxford, Oxford, U.K.

7. Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Road, Oxford OX1 3SY, U.K.

8. Oxford National Institute of Health Research, Biomedical Research Centre, Oxford, U.K.

9. Institute of Cancer Research, Old Brompton Road, London SW7 3RP, U.K.

10. Department of Mathematics, Ludwig-Maximilians-University Munich, Theresienstrasse 39, 80333 Munich, Germany.

11. Department of Paediatrics, Imperial College London, London, U.K.

12. Blizard Institute, Queen Mary University of London, London, U.K.

13. KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH), University of KwaZulu-Natal (UKZN), 4001 Durban, South Africa.

14. Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.

15. Department of Paediatric Infectious Diseases, Great Ormond Street Hospital for Children, London, U.K.

16. Paediatric Department, Kimberley Hospital, Northern Cape, South Africa.

17. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139–4307, USA.

18. Max Planck Institute for Infection Biology, Berlin, Germany.

19. Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

20. Center for the AIDS Programme of Research in South Africa (CAPRISA), 4001 Durban, South Africa.

Abstract

Pediatric HIV patients who do not rapidly develop AIDS are shown to have immunological features similar to nonhuman primates that experience nonpathogenic SIV infection.

Funder

NIH

South African Medical Research Council Strategic Health Innovation Partnerships (SHIP)

South African Research Chairs Initiative (SARChI)

National Research Foundation of South Africa

Wellcome Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference66 articles.

1. T Cell Activation Is Associated with Lower CD4+T Cell Gains in Human Immunodeficiency Virus–Infected Patients with Sustained Viral Suppression during Antiretroviral Therapy