Evaluation of Accessory Gene Regulator ( agr ) Group and Function in the Proclivity towards Vancomycin Intermediate Resistance in Staphylococcus aureus-Reference-Cited by-同舟云学术

Evaluation of Accessory Gene Regulator ( agr ) Group and Function in the Proclivity towards Vancomycin Intermediate Resistance in Staphylococcus aureus

Published:2007-03 Issue:3 Volume:51 Page:1089-1091
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Tsuji Brian T.¹²³,Rybak Michael J.¹⁴²,Lau Kerry L.¹,Sakoulas George⁵

Affiliation:

1. Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences

2. Detroit Receiving Hospital and University Health Center, Detroit, Michigan 48201

3. University at Buffalo, School of Pharmacy and Pharmaceutical Sciences, Buffalo, New York 14260

4. School of Medicine, Wayne State University

5. Department of Medicine, Division of Infectious Diseases, New York Medical College, Munger Pavilion 245, Valhalla, New York, 10595

Abstract

ABSTRACT Simulated therapeutic vancomycin exposures were evaluated against agr wild-type and knockout Staphylococcus aureus groups I, II, III, and IV using an in vitro pharmacodynamic model. All agr groups developed intermediate resistance to vancomycin after subtherapeutic exposure. The free unbound fraction of the area under the concentration-time curve ( f AUC/MIC) required to suppress resistance was fourfold higher ( P < 0.001) in agr dysfunctional strains (112 to 169) than that in parent wild-type strains (28).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00671-06

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