Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus

Author:

Cui Longzhu12,Tominaga Eiji2,Neoh Hui-min1,Hiramatsu Keiichi12

Affiliation:

1. Department of Bacteriology

2. Department of Infection Control Science, Juntendo University, 2-1-1 Bunkyo-Ku, Tokyo, Japan 113-8421

Abstract

ABSTRACT We present here findings of a strong positive correlation between reduced daptomycin susceptibility and vancomycin resistance in vancomycin-intermediate Staphylococcus aureus (VISA). This correlation is related to cell wall thickening, suggesting that, similar to the case with vancomycin resistance in VISA, the physical barrier of a thickened cell wall may contribute to daptomycin resistance in S. aureus .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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