Affiliation:
1. Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA.
Abstract
The synthesis of virulence factors and other extracellular proteins by
Staphylococcus aureus
is globally controlled by the
agr
locus, which encodes a two-component signaling pathway whose activating ligand is an
agr
-encoded autoinducing peptide. The cognate peptides produced by some strains inhibit the expression of
agr
in other strains, and the amino acid sequences of peptide and receptor are markedly different between such strains, suggesting a hypervariability-generating mechanism. Cross-inhibition of gene expression represents a type of bacterial interference that could be correlated with the ability of one strain to exclude others from infection or colonization sites, or both.
Publisher
American Association for the Advancement of Science (AAAS)
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