Molecular Basis of Functional Effects of Phosphorylation of the C-Terminal Domain of the Rabies Virus P Protein-Reference-Cited by-同舟云学术

Molecular Basis of Functional Effects of Phosphorylation of the C-Terminal Domain of the Rabies Virus P Protein

Published:2022-05-11 Issue:9 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Zhan Jingyu¹,Watts Ericka²,Brice Aaron M.²,Metcalfe Riley D.¹^ORCID,Rozario Ashley M.³,Sethi Ashish¹,Yan Fei¹,Bell Toby D. M.³,Griffin Michael D. W.¹,Moseley Gregory W.²^ORCID,Gooley Paul R.¹^ORCID

Affiliation:

1. Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia

2. Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

3. School of Chemistry, Monash University, Clayton, Victoria, Australia

Abstract

Rabies virus P protein is a multifunctional protein with critical roles in replication and manipulation of host-cell processes, including subversion of immunity. This functional diversity involves interactions of several P protein isoforms with the cell nucleus and microtubules.

Funder

Department of Health | National Health and Medical Research Council

Department of Education and Training | Australian Research Council

Grimwade Fellowship, Meigunyah Fund

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00111-22

Reference74 articles.

1. The importance of immune evasion in the pathogenesis of rabies virus