Affiliation:
1. Department of Microbiology and Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia
Abstract
Viruses commonly antagonize the antiviral type I interferon response by targeting signal transducer and activator of transcription 1 (STAT1) and STAT2, key mediators of interferon signaling. Other STAT family members mediate signaling by diverse cytokines important to infection, but their relationship with viruses is more complex. Importantly, virus-STAT interaction can be antagonistic or stimulatory depending on diverse viral and cellular factors. While STAT antagonism can suppress immune pathways, many viruses promote activation of specific STATs to support viral gene expression and/or produce cellular conditions conducive to infection.
Funder
Australian Government Research Training Program
Department of Health | National Health and Medical Research Council
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology