Candida glabrata Med3 Plays a Role in Altering Cell Size and Budding Index To Coordinate Cell Growth

Abstract

This study demonstrates that Cg Med3AB can regulate cell growth in C. glabrata by coordinating the homeostasis of cellular acetyl-CoA metabolism and the cell cycle cyclin Cg Cln3. Specifically, we report that Cg Med3AB regulates the cellular acetyl-CoA level, which induces the transcription of Cgcln3 , finally resulting in alterations to the cell size and budding index. In conclusion, we report that Cg Med3AB functions as a wheel responsible for driving cellular acetyl-CoA metabolism, indirectly inducing the transcription of Cgcln3 and coordinating cell growth. We propose that Mediator subunits may represent a vital regulatory target modulating cell growth in C. glabrata .