Candida glabrata Yap6 Recruits Med2 To Alter Glycerophospholipid Composition and Develop Acid pH Stress Resistance

Abstract

This study investigated the function of the Mediator tail subunit Cg Med2 in C. glabrata under low-pH stress. The protein kinase Cg Yak1 activates Cg Yap6 for the recruitment of Cg Med2, which in turn increases glycerophospholipid content and membrane integrity to confer low-pH stress tolerance. This study establishes a new link between the Mediator tail subunit and transcription factors. Overall, these findings indicate that Cg Med2 is a novel target to induce the low-pH stress response in C. glabrata .