The Guanine Nucleotide Exchange Factor GBF1 Participates in Rotavirus Replication-Reference-Cited by-同舟云学术

The Guanine Nucleotide Exchange Factor GBF1 Participates in Rotavirus Replication

Published:2019-10 Issue:19 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Martínez José L.¹^ORCID,Arnoldi Francesca²³,Schraner Elisabeth M.⁴,Eichwald Catherine⁴,Silva-Ayala Daniela¹,Lee Eunjoo⁵,Sztul Elizabeth⁵,Burrone Óscar R.²,López Susana¹,Arias Carlos F.¹^ORCID

Affiliation:

1. Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México

2. International Centre for Genetic Engineering and Biotechnology, Trieste, Italy

3. Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy

4. Institute of Virology, University of Zurich, Zurich, Switzerland

5. Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA

Abstract

Rotavirus, a member of the family Reoviridae , is the major cause of severe diarrhea in children and young animals worldwide. Despite significant advances in the characterization of the biology of this virus, the mechanisms involved in morphogenesis of the virus particle are still poorly understood. In this work, we show that the guanine nucleotide exchange factor GBF1, relevant for COPI/Arf1-mediated cellular vesicular transport, participates in the replication cycle of the virus, influencing the correct processing of viral glycoproteins VP7 and NSP4 and the assembly of the virus surface proteins VP7 and VP4.

Funder

Consejo Nacional de Ciencia y Tecnología

UNAM | Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01062-19

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