Mature Rotavirus Particles Contain Equivalent Amounts of 7me GpppG-Capped and Noncapped Viral Positive-Sense RNAs

Author:

Moreno-Contreras Joaquin1,Sánchez-Tacuba Liliana234,Arias Carlos F.1ORCID,López Susana1ORCID

Affiliation:

1. Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México

2. Department of Medicine, Division of Gastroenterology and Hepatology, Stanford School of Medicine, Stanford, California, USA

3. Department of Microbiology and Immunology, Stanford School of Medicine, Stanford, California, USA

4. VA Palo Alto Health Care System, Department of Veterans Affairs, Palo Alto, California, USA

Abstract

Rotaviruses have a genome composed of 11 segments of double-stranded RNA. Whether all 5′ ends of the positive-sense genomic RNAs contained in the mature viral particles are modified by a cap structure is unknown.

Funder

Consejo Nacional de Ciencia y Tecnología

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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