N-Glycosylation of Rotavirus NSP4 Protein Affects Viral Replication and Pathogenesis-Reference-Cited by-同舟云学术

N-Glycosylation of Rotavirus NSP4 Protein Affects Viral Replication and Pathogenesis

Published:2023-01-31 Issue:1 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Nurdin Jeffery A.¹,Kotaki Tomohiro¹,Kawagishi Takahiro¹,Sato Shintaro¹^ORCID,Yamasaki Moeko¹,Nouda Ryotaro¹,Minami Shohei¹^ORCID,Kanai Yuta¹,Kobayashi Takeshi¹²^ORCID

Affiliation:

1. Department of Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

2. Center for Infectious Disease Education and Research, Osaka University, Osaka, Japan

Abstract

Rotavirus is the main cause of gastroenteritis in young children and infants worldwide, contributing to 128,500 deaths each year. Here, we used a reverse genetics approach to examine the role of NSP4 N-glycosylation.

Funder

Japan Agency for Medical Research and Development

MEXT | Japan Society for the Promotion of Science

MEXT | Japan Science and Technology Agency

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01861-22

Reference58 articles.

1. The effect of rotavirus vaccine on diarrhoea mortality