An SHV-Derived Extended-Spectrum β-Lactamase in Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

An SHV-Derived Extended-Spectrum β-Lactamase in Pseudomonas aeruginosa

Published:1999-05 Issue:5 Volume:43 Page:1281-1284
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Naas Thierry¹²,Philippon Laurence¹,Poirel Laurent¹,Ronco Esthel³,Nordmann Patrice¹

Affiliation:

1. Service de Bactériologie-Virologie, Hôpital de Bicêtre, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre,1

2. Service de Bactériologie-Virologie, Hôpital Antoine Béclère, Faculté de Médecine Paris-Sud, 92141 Clamart Cedex,2 and

3. Service de Microbiologie, Hôpital Raymond Poincaré, Facultéde Médecine Paris-Ouest, 92380 Garches,3Assistance Publique/Hôpitaux de Paris, France

Abstract

ABSTRACT A clinical isolate of Pseudomonas aeruginosa RP-1 produced the extended-spectrum β-lactamase (ESBL) SHV-2a. Its gene was expressed from a composite promoter made of the −35 region derived from the left inverted repeat of IS 26 and the −10 region from the bla SHV-2a promoter itself. The DNA sequences immediately surrounding bla SHV-2a were homologous to plasmid pMPA2a from Klebsiella pneumoniae KpZU-3, while further away and 3′ to the bla SHV-2a gene, a sequence corresponding to the left end of Tn 1721 was detected, thus indicating a likely enterobacterial origin of this ESBL gene.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.5.1281

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