Role of Mfd and GreA in Bacillus subtilis Base Excision Repair-Dependent Stationary-Phase Mutagenesis

Author:

Leyva-Sánchez Hilda C.1,Villegas-Negrete Norberto1,Abundiz-Yañez Karen1,Yasbin Ronald E.2,Robleto Eduardo A.3,Pedraza-Reyes Mario1

Affiliation:

1. Department of Biology, Division of Natural and Exact Sciences, University of Guanajuato, Guanajuato, Mexico

2. College of Arts and Sciences, University of Missouri—St. Louis, St. Louis, Missouri, USA

3. School of Life Sciences, University of Nevada, Las Vegas, Nevada, USA

Abstract

In this paper, we report that spontaneous genetic lesions of an oxidative nature in growing and nutritionally stressed B. subtilis strain YB955 ( hisC952 metB5 leuC427 ) cells drive Mfd- and GreA-dependent repair transactions. However, whereas Mfd and GreA elicit faithful repair events during growth to maintain genome fidelity, under starving conditions, both factors promote error-prone repair to produce genetic diversity, allowing B. subtilis to escape from growth-limiting conditions.

Funder

CONACYT

University of Guanajuato

HHS | NIH | NIH Office of the Director

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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