EFFECTS OF ASPARTATE ON GROWTH AND ON THE SYNTHESIS OF α-AMYLASE IN PSEUDOMONAS SACCHAROPHILA

Abstract

Eisenstadt, Jerome M. (Brandeis University, Waltham, Mass.), and Harold P. Klein . Effects of aspartate on growth and on the synthesis of α-amylase in Pseudomonas saccharophila . J. Bacteriol. 87: 1355–1363. 1964.—Protein synthesis by starch-grown cells of Pseudomonas saccharophila is inhibited by low concentrations of d -aspartate, whereas assimilation continues for several hours under these conditions. These effects are also observed when the cells are grown with cellobiose or maltose, but not with a wide variety of other carbon sources. l -Aspartate at a ratio of about 6:1 completely reverses these effects, whereas adenosine partially does so. One possible basis of the inhibitory effects of d -aspartate is in the synthesis of adenosine from inosine.