Antibiotic Metabolites from a Marine Pseudomonad

Author:

Wratten Stephen J.1,Wolfe Margaret S.1,Andersen Raymond J.1,Faulkner D. John1

Affiliation:

1. Scripps Institution of Oceanography, La Jolla, California 92093

Abstract

An antibiotic-producing pseudomonad was isolated from a seawater sample from a La Jolla, Calif., tidepool. The pseudomonad produces two novel antibacterial compounds, 2- n -pentyl-4-quinolinol and 2- n -heptyl-4-quinolinol. It also synthesizes indole-3-carboxaldehyde, 6-bromoindole-3-carboxaldehyde, and the known antibiotic p -hydroxybenzaldehyde. Each of these compounds was identified by analysis of spectral data, and the structures were confirmed by synthesis or comparison with authentic samples.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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