Author:
Hang Nguyen Thi Thuy,Yen Tran Thi,Hoang Vu Dinh,Quoc Anh Ngo
Abstract
Five new 4-aza-2,3-didehydropodophyllotoxins were synthesized by a straightforward multi-component reaction in the hope of finding new structures with interesting anticancer activity. The “one-pot” synthesis process is developed to increase performance as well as minimize the steps involved. The obtained compounds with podophyllotoxin frame have the corresponding yields of 60-83%. Five new 4-aza-2,3-didehydropodophyllotoxins demonstrated comparable cytotoxicity against the Hep-G2, MCF7cell lines with an IC50 value of 52.2 - 261.2 µM with ellipsitine as the positive control.
Publisher
Publishing House for Science and Technology, Vietnam Academy of Science and Technology (Publications)
Reference24 articles.
1. Wratten S. J., Wolfe M. S., Andersen R. J., and Faulkner D. J. - Antibiotic Metabolites from a Marine Pseudomonad, Antimicrob. Agents Chemother. 11 (3) (1977) 411-414.
2. Berger J. M. and Wang J. C. - Recent developments in DNA topoisomerase II structure and mechanism, Curr. Opin. Struct. Biol. 6 (1) (1996) 84-90.
3. Sakurai H., Miki T., Imakura Y., Shibuya M. - Metal- and photo-induced cleavage of DNA by podophyllotoxin, etoposide, and their related compounds, Mol. Pharmacol. 40 (6) (1991) 965-973.
4. Huang T. S., Shu C. H., Shih Y. L., Huang H. C. - Protein tyrosine phosphatase activities are involved in apoptotic cancer cell death induced by GL-331, a new homolog of etoposide, Cancer Lett. 110 (1996) 77-85.
5. Huang T. S., Shu C. H., Yang W. K., Whang-Peng J. - Activation of CDC 25 phosphatase and CDC2 kinase involved in GL-331- induced apoptosis, Cancer Res. 57 (14) (1997) 2974-2978.