SHV-49, a Novel Inhibitor-Resistant β-Lactamase in a Clinical Isolate of Klebsiella pneumoniae-Reference-Cited by-同舟云学术

SHV-49, a Novel Inhibitor-Resistant β-Lactamase in a Clinical Isolate of Klebsiella pneumoniae

Published:2004-11 Issue:11 Volume:48 Page:4466-4469
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Dubois Véronique¹,Poirel Laurent²,Arpin Corinne¹,Coulange Laure¹,Bebear Cécile³,Nordmann Patrice²,Quentin Claudine¹

Affiliation:

1. Laboratoire de Microbiologie, Faculté de Pharmacie, Université de Bordeaux 2

2. Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre cedex, France

3. Laboratoire de Bactériologie, Hôpital Pellegrin, Bordeaux

Abstract

ABSTRACT A clinical strain of Klebsiella pneumoniae carried the bla SHV-49 gene, encoding a novel inhibitor-resistant β-lactamase of pI 7.6, derived from SHV-1 by the single substitution M69I. It also harbored a gene differing from bla SHV-11 by four silent mutations and coding for a penicillinase. Both genes were chromosome located and might represent either a species-specific gene or an acquired resistance gene.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.11.4466-4469.2004

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