Affiliation:
1. Department of Chemistry, Bose Institute, Calcutta 700 009, India
Abstract
ABSTRACT
A β-lactamase with an
M
r
of 29,000 and a pI of 7.6 was partially purified from a clinical isolate of
Shigella dysenteriae
. The
bla
gene encoded the SHV-11 enzyme carrying the substitution Leu→Gln at position 35 and was linked to a strong promoter. This variant, unlike the prototype SHV-1 enzyme, hydrolyzed oxacillin, cloxacillin, and oxyiminocephalosporins such as cefotaxime.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
30 articles.
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