Author:
Sutyak Noll Katia,Prichard Mark N.,Khaykin Arkady,Sinko Patrick J.,Chikindas Michael L.
Abstract
ABSTRACTSubtilosin is a cyclical antimicrobial peptide produced byBacillus amyloliquefaciensthat has antimicrobial activity against the bacterial vaginosis-associated human pathogenGardnerella vaginalis. The ability of subtilosin to inhibitG. vaginalisalone and in combination with the natural antimicrobial agents glycerol monolaurate (Lauricidin), lauric arginate, and ε-poly-l-lysine was tested using a checkerboard approach. Subtilosin was found to act synergistically with all of the chosen antimicrobials. These promising results indicate that lower concentrations of subtilosin in combination with other compounds could effectively be used to inhibit growth of the pathogen, thereby decreasing the risk of developed antimicrobial resistance. This is the first report on the effects of subtilosin combined with other natural antimicrobials againstG. vaginalis.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
42 articles.
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