Balancing Positive and Negative Selection: In Vivo Evolution of Candida lusitaniae MRR1-Reference-Cited by-同舟云学术

Balancing Positive and Negative Selection: In Vivo Evolution of Candida lusitaniae MRR1

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Demers Elora G.¹^ORCID,Stajich Jason E.²^ORCID,Ashare Alix³^ORCID,Occhipinti Patricia¹,Hogan Deborah A.¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA

2. Department of Microbiology & Plant Pathology and Institute for Integrative Genome Biology, University of California—Riverside, Riverside, California, USA

3. Dartmouth-Hitchcock Medical Center, Section of Pulmonary and Critical Care Medicine, Lebanon, New Hampshire, USA

Abstract

Understanding microbial evolution within patients is critical for managing chronic infections and understanding host-pathogen interactions. Here, our analysis of multiple MRR1 alleles in isolates from a single Clavispora ( Candida ) lusitaniae infection revealed the selection for both high and low Mrr1 activity.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of General Medical Sciences

Cystic Fibrosis Foundation

HHS | NIH | National Cancer Institute

National Science Foundation

HHS | NIH | NIH Office of the Director

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Society for Microbiology

Subject