Transcriptional Regulation of Carnitine Catabolism in Pseudomonas aeruginosa by CdhR-Reference-Cited by-同舟云学术

Transcriptional Regulation of Carnitine Catabolism in Pseudomonas aeruginosa by CdhR

Published:2018-02-28 Issue:1 Volume:3 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Meadows Jamie A.¹,Wargo Matthew J.¹²

Affiliation:

1. Department of Microbiology and Molecular Genetics, University of Vermont Larner College of Medicine, Burlington, Vermont, USA

2. The Vermont Lung Center, University of Vermont Larner College of Medicine, Burlington, Vermont, USA

Abstract

Pathogens must metabolize host-derived compounds during infection and properly regulate the responsible pathways. Carnitine is a common eukaryotic-associated quaternary amine compound that can be catabolized by Pseudomonas aeruginosa . Here we expand on our understanding of how this metabolic pathway is regulated and provide details on how carnitine catabolism is intertwined with glycine betaine catabolism at the level of transcriptional control.

Funder

HHS | National Institutes of Health

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00480-17

Reference44 articles.

1. Agricultural Plants and Soil as a Reservoir for Pseudomonas aeruginosa