Elucidation of DNA Repair Function of PfBlm and Potentiation of Artemisinin Action by a Small-Molecule Inhibitor of RecQ Helicase-Reference-Cited by-同舟云学术

Elucidation of DNA Repair Function of PfBlm and Potentiation of Artemisinin Action by a Small-Molecule Inhibitor of RecQ Helicase

Published:2020-12-23 Issue:6 Volume:5 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Suthram Niranjan¹,Padhi Siladitya²,Jha Payal¹,Bhattacharyya Sunanda³,Bulusu Gopalakrishnan²,Roy Arijit²,Bhattacharyya Mrinal Kanti¹^ORCID

Affiliation:

1. Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India

2. TCS Innovation Labs-Hyderabad (Life Sciences Division), Tata Consultancy Services Limited, Hyderabad, India

3. Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India

Abstract

Malaria continues to be a serious threat to humankind not only because of the morbidity and mortality associated with the disease but also due to the huge economic burden that it imparts. Resistance to all available drugs and the unavailability of an effective vaccine cry for an urgent discovery of newer drug targets.

Funder

Department of Biotechnology, Ministry of Science and Technology, India

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00956-20

Reference59 articles.

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2. DNA Double-strand Breaks: Their Repair and Relationship to Cell Killing in Yeast

3. Dominant negative mutant ofPlasmodium Rad51 causes reduced parasite burden in host by abrogating DNA double-strand break repair