<i>Plasmodium</i> Topoisomerase VIB and Spo11 Constitute Functional Type IIB Topoisomerase in Malaria Parasite: Its Possible Role in Mitochondrial DNA Segregation-Reference-Cited by-同舟云学术

Plasmodium Topoisomerase VIB and Spo11 Constitute Functional Type IIB Topoisomerase in Malaria Parasite: Its Possible Role in Mitochondrial DNA Segregation

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Singh Priyanka¹,Tabassum Wahida²,Fangaria Nupur¹,Dey Sandeep³,Padhi Siladitya⁴,Bhattacharyya Mrinal K.²^ORCID,Arun Kumar Kota³,Roy Arijit⁴,Bhattacharyya Sunanda¹^ORCID

Affiliation:

1. Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India

2. Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India

3. Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, India

4. TCS Research-Hyderabad (Life Sciences Division), Tata Consultancy Services Limited, Hyderabad, India

Abstract

This study demonstrates a likely role of topoisomerase VI in the mitochondrial genome segregation of Plasmodium falciparum during endoreduplication. We show that PfTopoVIB and PfSpo11 remain associated and form the functional holoenzyme within the parasite.

Funder

Department of Biotechnology, Ministry of Science and Technology, India

Department of Science and Technology, Ministry of Science and Technology, India

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04980-22

Reference27 articles.

1. World Health Organization. 2021. World malaria report 2021. https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2021.

2. A tale of topoisomerases and the knotty genetic material in the backdrop of Plasmodium biology

3. DNA Topoisomerase VI Is Essential for Endoreduplication in Arabidopsis

4. Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle ofPlasmodium falciparum

5. Radicicol-Mediated Inhibition of Topoisomerase VIB-VIA Activity of the Human Malaria Parasite Plasmodium falciparum

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