Reconstitution of Mycobacterium marinum Nonhomologous DNA End Joining Pathway in <i>Leishmania</i>-Reference-Cited by-同舟云学术

Reconstitution of Mycobacterium marinum Nonhomologous DNA End Joining Pathway in Leishmania

Published:2022-06-29 Issue:3 Volume:7 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Zhang Wen-Wei¹^ORCID,Wright Douglas G.²,Harrison Lynn²,Matlashewski Greg¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada

2. Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA

Abstract

Nonhomologous end joining (NHEJ) is the most efficient double-stranded DNA break (DSB) repair pathway in mammalian cells. In contrast, the protozoan parasite Leishmania has no functional NHEJ pathway but retains the core NHEJ factors of Ku70 and Ku80 proteins.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00156-22

Reference66 articles.

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5. Comparison of nonhomologous end joining and homologous recombination in human cells

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